Featured publications

Variation in the life history strategy underlies functional diversity of tumors
Key words
density-dependent selection, trade-offs, cancer cell,phenotypic
diversity, competition

EVOLUTIONARY BIOLOGY
From asymmetrical to balanced genomic diversification During rediploidization:Subgenomic evolution in allotetraploid fish
Genomic evolution,Allotetraploid goldfish,Rediploidization polyploidy
Key words

Genetic Load and Potential Mutational
Meltdown in Cancer Cell Populations
Key words
genetic load, Muller’s ratchet, HeLa cell line, copy number variation

A Direct Test of Selection in Cell Populations Using the Diversity in Gene Expression within Tumors
genetic diversity, intra- and intertumor heterogeneity, selection
Key words

Functional Conservation of Both CDS- and
3’-UTR -Located MicroRNA Binding Sites between Species
Key words
microRNA, CDS targets, 3’-UTR targets, conservation

Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution
intratumor heterogeneity, genetic diversity, neutral- evolution, cancer
evolution, natural selection
Key words

The dynamics of DNA methylation
fidelity during
mouse embryonic stem cell self-renewal and differentiation
Key words
Methylation,methylation fidelity,mouse embryonic stem cells

The Ecology and
Evolutionof
Cancer: The Ultra-Microevolutionary Process
cancer evolution, natural selection, convergent evolution,
cell population, genetics, intratumor heterogeneity
Key words

Histone Demethylase KDM4B Promotes
DNA Damage by Activating Long Interspersed Nuclear Element-1
Key words
H3K9me3 ,LINE-1, KDM4B, tumorigenesis, DNAdamage

Free-living human cells reconfigure their chromosomes in the evolution back to uni-cellularity
cancer cell line,sex chromosome evolution, uni-cellularity
Key words